Hemopexin activity and extracellular ATP in the pathogenesis of preeclampsia Spaans, Floor
نویسندگان
چکیده
Preeclampsia is a multisystem complication in the second half of the pregnancy and characterized by hypertension and proteinuria. Although its specific pathophysiology is largely unknown, poor placentation, generalized inflammation and endothelial cell dysfunction are playing important roles. Recently, increased plasma levels of extracellular ATP have been found in women with preeclampsia. This increased ATP is considered to contribute to the development of the disease, since extracellular ATP has been shown to be a danger signal in many diseases. Extracellular ATP may increase blood pressure and activate endothelial cells and immune cells. In the circulation, ATP can be dephosphorylated to adenosine, which counteracts the effects of ATP. In the present review, we describe the importance of the delicate balance between extracellular ATP and adenosine in pregnancy and preeclampsia.
منابع مشابه
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